LISTERINE® Antiseptic is the most extensively tested OTC mouthrinse in the world, with over 30 long-term clinical trials examining its safety and efficacy.1-10 Numerous studies over the past 40 years have shown that there is no negative impact detected in the use of mouthrinses containing alcohol.5-10, ,Clinical studies, meta-analyses, quantitative analyses, and systematic reviews of data have demonstrated that there is no causal link between the use of LISTERINE® Antiseptic mouthrinse and oral cancer or xerostomia.2-10, , ,Clinical study findings,Clinical study findings,LISTERINE® Antiseptic met specific guidelines for Chemotherapeutic Products for Control of Gingivitis category, including carcinogenicity and mutagenicity studies to assess possible adverse effects at the cellular level. 12*,
,*Contact the ADA for more information on the ADA Seal and to obtain Seal guidelines.,
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Clearing up Mouthrinse Misinformation: Understanding the Safety and Uses of Alcohol in Mouthrinses

