A pioneering dental treatment could offer hope to millions suffering from tooth decay. Scientists at the University of Nottingham, collaborating with international researchers, have developed a protein-based gel that can repair and regenerate damaged tooth enamel.
Currently, no solution exists to regrow enamel—a condition affecting nearly half of the global population and costing an estimated $544 billion annually.
The gel, described as safe, easy to apply, and scalable, works like traditional fluoride treatments but goes further by actively rebuilding enamel. “The technology is versatile and can be adapted into various products to help patients of all ages with enamel loss or exposed dentine,” said Professor Alvaro Mata, Chair in Biomedical Engineering & Biomaterials.
The treatment, being commercialized by the start-up Mintech-Bio, could be on the market next year. It mimics the natural proteins that guide enamel growth during infancy, creating a strong layer that fills cracks and holes while using calcium and phosphate from saliva to stimulate mineral growth.
Dr. Abshar Hasan, a postdoctoral fellow leading the study, explained that the gel promotes crystal growth in an organized manner, restoring the structure of healthy enamel.
Tests simulating real-life conditions, including chewing, tooth brushing, and acidic food exposure, showed that the regenerated enamel behaves like natural enamel.
Developed by the University of Nottingham’s School of Pharmacy and Department of Chemical and Environmental Engineering, the gel represents a major advance in dental care, potentially transforming treatments for patients worldwide.
