Pearl and vVARDIS have announced a collaboration to support dental professionals in detecting and managing early-stage dental caries using artificial intelligence and a topical, drill-free treatment.
The collaboration combines Pearl’s AI-powered radiologic detection tool, Second Opinion, with vVARDIS’s Curodont™ line of biomimetic products, designed for non-invasive treatment of early decay. According to the companies, the partnership seeks to streamline workflows for clinicians by allowing diagnosis and treatment of early carious lesions during the same appointment.
“At Pearl, we are dedicated to enhancing and standardizing dental diagnostics by leveraging AI to simplify radiograph interpretation and improve patient communication,” said Ophir Tanz, CEO and founder of Pearl. “Our collaboration with vVARDIS enables a comprehensive, internationally scalable approach to early intervention against dental decay, giving patients more options for an effective and proactive path to improved oral health.”
Pearl reports that its Second Opinion platform uses AI to assist clinicians in identifying early signs of decay and other dental conditions on radiographs. According to the company, this technology also helps improve patient understanding of their conditions, potentially increasing acceptance of recommended treatments.
vVARDIS’s Curodont™ offers a brush-on formulation intended to promote hydroxyapatite formation during the early stages of decay. According to the company, this approach preserves natural tooth structure and avoids traditional drilling and fillings. The treatment can be applied during the same visit when decay is detected.
“Partnering with Pearl is a natural progression in our mission to provide innovative solutions for early stage dental decay,” said Jeremy Thomas, president of vVARDIS North America. “This collaboration equips global dental professionals with modern tools to detect conditions sooner and provides a proven, non-invasive solution to help restore enamel health.”
Haley Abivardi, DMD, and Dr. Goly Abivardi, DMD, co-founders and Co-CEOs of vVARDIS, emphasized the impact of untreated dental disease on education and productivity. Dental professionals have been waiting for decades for a drill-free treatment that addresses the sub-clinical signs of caries in the same visit, they said. They also noted that with its integration into existing clinical workflows, Curodont™ may allow more dental professionals to manage early-stage caries without resorting to restorative procedures.
According to vVARDIS, studies show that up to 80 percent of patients present with early decay. The company points to more than 200 publications supporting the effectiveness of its approach, including real-world evidence studies.
Pearl, based in Los Angeles, California, reports that its dental AI tools are cleared for use in 120 countries. vVARDIS, headquartered in Zug, Switzerland, was founded by practicing dentists and entrepreneurs.

