Researchers at the University Zurich have mapped the first complete atlas of single cells that make up the human teeth. Their research shows that the composition of human dental pulp and periodontium vary greatly. Their findings open up new avenues for cell-based dental therapeutic approaches. During the last 30 years, medical and dental research has attracted a large number of scientists and practitioners working on aspects of high medical relevance

Researchers at the University of Birmingham, UK, led by Dr. Ben Scheven, Dr. Wendy Leadbeater and Ben Mead have discovered that stem cells isolated from the teeth, termed dental pulp stem cells (DPSC), can protect retinal ganglion cells (RGCs) from death following injury and promote regeneration of their axons along the optic nerve. RGC loss is the leading cause of blindness and can arise through traumatic injury or degenerative diseases

Deafness is a condition in which the hearing diminishes or disappears; currently there are few procedures to treat because it often is irreversible. Also, according to the World Health Organization (WHO), the disease globally affects 360 million people. In response, Oscar Omar Solis Castro, who is on his doctorate in biomedical sciences at the University of Sheffield, England, uses stem cells derived from dental pulp for use in the regeneration

Today, the International and American Associations for Dental Research (IADR/AADR) published a paper titled “–catenin is Required in Odontoblasts for Tooth Root Formation.” The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research. The tooth root, together with the surrounding periodontium, maintains the tooth in the jaw. The root develops

The interplay between the nervous and stomatognathic systems, both anatomically proximate and functionally intertwined, holds profound implications for health. Advances in brain science reveal significant crosstalk between the two systems, thus underpinning emergent concepts like neuromuscular dentistry and stomatopsychology. From craniomaxillofacial development to nerve-bone regulation, this relationship dictates both systems’ health. Understanding their mutual influence can elucidate the neurological effects of oral ailments and vice versa, ultimately offering new approaches

 Biotechnology Center of the TU Dresden (BIOTEC), have found that stem cells could be used for several forms of tissue engineering including tooth repair. Study leader Dr Bing Hu of the Peninsula Dental School of the University of Plymouth, published the results of the study titled, “Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation,” in the journal Nature Communications. The image shows a group of mesenchymal (green) stem cells

A new chemical solution jointly developed by the University of Adelaide’s Dental School and Australian company Dentalife could radically reduce the chance of infection associated with root canal work. Every year millions of root canal treatments are performed globally (more than 22 million in the USA alone). The management of root canal bacteria helps to prevent complications such as oral and facial infections. These have a profound effect on the

Peripheral nerve injuries often are caused by trauma or surgical complications and can result in considerable disabilities. Regeneration of peripheral nerves can be accomplished effectively using autologous (self-donated) nerve grafts, but that procedure may sacrifice a functional nerve and cause loss of sensation in another part of the patient’s body. Searching for an alternative to autologous nerve grafts (autografts), researchers in Japan transplanted mobilized dental pulp stem cells (MDPSCs) into

Few patients regret having a severely damaged tooth saved by a root canal filling. A University of Gothenburg thesis shows that 87 percent would choose the same treatment again, if in need, although pain and discomfort around the tooth are common. The reason for getting a root filling is often that the soft tissue inside the tooth, the dental pulp, is inflamed or infected. The root canal treatment is carried out in

A root canal ranks high on most people’s list of dreaded dental procedures. Although the lengthy and sometimes painful surgery relieves the agony of an infection, a root canal results in a dead tooth with no living soft tissue, or dental pulp, inside. Today, scientists report development of a peptide hydrogel designed to stimulate the growth of new blood vessels and dental pulp within a tooth after the procedure. The

Stem cells. Few research discoveries hold as much promise of single-handedly expanding medical treatment options as they do. Miraculously able to act as transformers-;either re-creating or morphing into a variety of cell types found within the organisms they originate from-;stem cells offer humanity hope for new, more effective therapies against a number of chronic and terminal diseases. And finding them is surprisingly easy. “Stem cells can be extracted from nearly

Researchers report in Science Advances that they have uncovered a new function for odontoblasts, the cells that form dentin, the shell beneath the tooth’s enamel that encases the soft dental pulp containing nerves and blood vessels. We found that odontoblasts, which support the shape of the tooth, are also responsible for sensing cold. This research contributes a new function to this cell, which is exciting from a basic-science standpoint. But we now