FDA OKs human trial of RevBio’s bone adhesive biomaterial

RevBio has been given approval from the U.S. Food and Drug Administration (FDA) to start a 20-patient trial to study the safety and efficacy of its bone adhesive biomaterial, Tetranite. The clinical trial will explore a more rapidly replaced, pH-modified porous formulation of the biomaterial, which aims to immediately stabilize dental implants following tooth extractions. This new formulation has shown evidence of a more biologically active bone substitution. While not

Researchers create algorithms to track periodontal disease change

Researchers from Regenstrief Institute and Indiana University School of Dentistry have developed computer algorithms to track periodontal disease change. Their findings were published in Diagnostics. The team, led by Thankam Thyvalikakath, PhD, also developed tools that make way for the use of electronic dental record data to automate diagnosis of periodontal disease. Data from the U.S. Centers for Disease Control and Prevention (CDC) suggest that about 47% of adults aged

Researchers develop gene therapy for chronic oral pain

Researchers at the Pain Research Center in New York University’s College of Dentistry recently developed a gene therapy that treats chronic pain, their results being published in the Proceedings of the National Academy of Sciences (PNAS). The team, led by Rajesh Khanna, found that the therapy indirectly regulates the NaV1.7 sodium ion channel, made possible by the discovery of the precise region of the channel to control its activity. Sodium

Sonendo enhances its CleanFlow instrument

The CleanFlow instrument from Sonendo, the developer of the GentleWave root canal disinfection system, can now be used on anterior teeth. CleanFlow not only replaces the company’s Anterior Pre-Molar procedure Instrument, but it aims to improve the GentleWave process. Additionally, CleanFlow, which is designed for one-handed use, has been refined to direct more fluid energy into a tooth.

Common Dental Procedures: A Review of Fillings, Root Canals, and Extractions

Common Dental Procedures: A review of common dental procedures such as fillings, root canals, and extractions, including what to expect during the procedure, recovery time, and cost. It can get scary or at least intimidating to go to the dentist to do some common dental procedures. The big chairs, the X-ray machines, and the buzzing sounds might overwhelm you or at least overstimulate your imagination. Perhaps knowing about these dental

5 Benefits of Having All-on-4 Dental Implants in Mexico

All-on-4 dental implants have become one of the most important procedures in dentistry nowadays. Providing a permanent and effective solution to tooth loss, all on 4 dental implants in Mexico have proven to be one of the best choices you can make to regain your smile at an affordable price. Different destinations in Mexico, such as Los Algodones in Baja California are constantly welcoming patients who are looking to get

Toothbrush injury causes stroke in 2-year-old boy

A 2-year-old boy fell while brushing his teeth, causing a blunt cerebrovascular injury (BCVI) to the pharynx, and leading to an ischemic stroke, according to a clinical note published July 28 in Pediatrics International. The child remained paralyzed on the lower half of his body on the left side after treatment and a lengthy hospital stay, the authors wrote. “Early diagnosis and treatment are crucial to prevent the development of

Could an ancient signaling pathway hold the key to tooth formation?

Researchers at the University of Zurich Center for Dental Medicine recently studied the Notch pathway’s role in the evolution of tooth morphology, with their results being published in Cellular and Molecular Life Sciences. The team, led by Thimios Mitsiadis, PhD, suggested that mutations in this ancient signaling pathway can lead to defective structures in tooth enamel. Tooth analysis is often performed to study mammalian evolution and the adaptations that occur

Clear aligners may raise the risk of having a smile with gaps

Clear aligner therapy patients may not only be more likely to be left with open gingival embrasures than those treated with fixed orthodontics, but these gaps between the teeth may be larger, a study recently published in Head & Face Medicine found. Clinicians should know about the risk of open gingival embrasures (OGE) with clear aligner therapy and explain these potential consequences to patients, the authors wrote. “Despite an invisible

Researchers develop novel bone regeneration technique

A group at Tokyo Medical and Dental University (TMDU) suggests that bone repair can be improved in large bone lesions by injecting a combination of RNA, according to recent research. In a study in rats, the researchers demonstrated that injecting RNA encoding two different proteins involved in bone repair improved bone regeneration over large areas. They noted the finding could translate well into the clinic. “Our technique is especially promising

3rd-molar surgery may put patients at risk of developing TMDs

Patients who experience trauma such as wisdom teeth extractions may develop temporomandibular disorders (TMD), according to a review published recently in Cranio: the Journal of Craniomandibular and Sleep Practice. Although the association does not equal causation, there is a presurgical incidence of TMD in the patients seeking third molar extractions. “[Therefore], the importance of including a full temporomandibular joint pre-surgical assessment may lead to a reduced incidence of TMD in

SmileDirectClub expanding CarePlus plan in the U.S.

SmileDirectClub’s premium clear aligner offering, CarePlus, will be available at SmileShops in the U.S. and select partner network locations in August. CarePlus includes access to a local dentist or orthodontist for in-person check-ins, access to an all-day, every day concierge customer care team, expedited aligner shipping, and enhanced scalloped-edge aligners and retainers. The company decided to expand the offering after piloting CarePlus in four markets in the U.S. When paid