Does articaine damage neural cells more than lidocaine?
Reports of infrequent but prolonged paresthesias after the use of 4% articaine beg the question of whether this local anesthetic is more neurotoxic than lidocaine. To learn more, researchers conducted in vitro experiments that produced some unexpected results. They compared the neurotoxicity of these two commonly used drugs in neural cells by testing formulations used clinically in patients (2% lidocaine, 1:100,000 epinephrine or 4% articaine, 1:100,000 epinephrine) and also pure

